�Australian and American scientists have identified the origins of the most malignant type of brain neoplasm in a discovery that could pencil lead to better therapies and improve our understanding of how tumours initiate.
The team, lED by Professor Brandon Wainwright from the Institute for Molecular Bioscience at the University of Queensland in Brisbane, Australia, and Dr Robert Wechsler-Reya from Duke University in Durham, USA, studied medulloblastomas, which occur most a great deal in children.
"Almost half the people who develop these tumours die from them, and those world Health Organization survive often suffer life-threatening side personal effects from the treatment," Professor Wainwright said. "Improved treatments are urgently required, only in order to develop these, we need a deeper discernment of the molecular and cellular origins of medulloblastomas."
The squad found that medulloblastomas can originate from two types of cubicle: multipotent neuronal stem cells (NSCs) and granule nerve cell precursors (GNPs). NSCs are stem cells that canful become most types of cell within the nervous system, spell GNPs are similar to stem cells but alone give rise to one type of cells, known as granule neurons.
"There was good evidence that either cell type could be the origin of medulloblastomas, simply no one considered that both sets of evidence could be correct, and that these tumours could actually begin in two different cell types," Professor Wainwright aforementioned.
"Identifying the normal electric cell that gives rise to a neoplasm is important because it allows direct comparisons betwixt tumour cells and their normal counterparts so that key differences and vulnerabilities in the tumour stool be identified.
"Also, recent studies indicate that cells resembling the original cell may remain in suppurate tumours and can be critical in ensuring its survival. If so, these cells would be an excellent target for discussion."
The team made their discovery by examining a gene called Patched, which is involved in the regulation of both neuronic stem cells and GNPs. When the gene is inactivated, medulloblastomas develop.
However, when inactivation occurs, it happens in all cells, so in that location was no way of knowing in which cell the tumor had begun. The team took advantage of an allele, or version, of Patched that allows deactivation of the gene in either GNPs or neural stem cells, and establish that the tumours developed no issue in which cell Patched was inactivated.
The study could besides have wider implications for treating other types of cancer, as the team also plant that malignant neoplastic disease doesn't always originate in the same way.
"It has always been intellection that cells had to mutate respective times in front becoming a tumour," Professor Wainwright aforementioned. "In this study we found that some shank cells only needed to mutate once.
"They would not turn cancerous immediately, but in one case they had been granted an direction to turn into a more specialised cell, the mutation would take go for and they would instead turn into a tumor."
The study has been published in current yield of stellar scientific journal Cancer Cell
, and is funded by the National Health and Medical Research Council, the Australian Cancer Research Foundation, the Cancer Council QLD and the John Trivett Foundation.
The University of Queensland, Brisbane Australia
More info
Saturday, 16 August 2008
Thursday, 7 August 2008
Book offers criticism of U.S. president Abraham Lincoln
"Lincoln's Darkest Year - The War in 1862"
By William Marvel
Publisher: Houghton Mifflin Company
Either the fighting or the politics of 1862 - the
Friday, 27 June 2008
Jack Lancaster and Robin Lumley
Artist: Jack Lancaster and Robin Lumley
Genre(s):
New Age
Discography:
Marscape
Year: 1975
Tracks: 13
Scott Joplin
Monday, 23 June 2008
Monday, 16 June 2008
Thumbplay Launches Beta Version of SMS-based Mobile Entertainment Content Search
Consumers Can Text Message 'Get' To THUMB (84862) to Quickly and Easily
Search Through More Than 80,000 Pieces of Licensed Mobile Entertainment
Content
NEW YORK, June 16 -- Thumbplay(R) (http://www.thumbplay.com), the
#1 mobile entertainment destination in the U.S.*, has launched the beta
version of an innovative mobile search service that allows cell phone users
in the United States to instantly search for and purchase ringtones, games,
videos and wallpapers from their mobile phone or handheld device (like a
Blackberry).
Thumbplay's GET is an SMS-based search option that allows consumers to
search for mobile entertainment content from wherever they are. All a
consumer needs to do is send a text message with the word "Get" plus any
artist or song name to THUMB (84862) to find and download content from
their favorite artists. For example, to find all mobile content associated
with the band Coldplay, a user would simply send an SMS message to THUMB
(84862) with the phrase "Get Coldplay" and a link to relevant content
(e.g., songs, videos, wallpapers and/or associated games) will be sent back
from Thumbplay to their mobile phone within seconds. A user would then
follow this link (as long as their phone has Web access to retrieve the
links) to a large menu of licensed Coldplay content found in Thumbplay's
catalog, which they can browse without commitment and then purchase and
download.
"Thumbplay has maintained and grown its leadership position in the
industry by providing our consumers with the largest catalog and allowing
them to quickly and easily search for, find and download the mobile content
they want," said Are Traasdahl, CEO and founder of Thumbplay. "With GET,
we've made it simple for consumers to find and purchase their favorite
mobile content whenever and wherever they are -- even if they're not near a
computer."
GET streamlines the way consumers can search for, browse and download
mobile entertainment content from their cell phones, regardless of their
location. It enables them to find relevant content by keyword -- such as an
artist's name or a song or game title -- within Thumbplay's extensive
mobile catalog, which currently includes more than 80,000 pieces of
licensed audio, video and gaming content from many of the world's leading
music labels, artists and game publishers, as well as media and
entertainment companies.
Thumbplay has built a strong consumer following and gained broad
recognition as a leader in the direct-to-consumer mobile content space.
During the last quarter of 2007, Thumbplay announced deals to integrate its
mobile entertainment content catalog into the Web and mobile portals of AOL
and MSN Mobile, as well as iLike, one of the Web's leading social music
discovery services.
Earlier this year, Thumbplay signed a digital distribution agreement to
add content from Sony BMG Music Entertainment's artists to Thumbplay's
already diverse mobile entertainment catalog, as well as to roll out mobile
content stores on the Web sites for Entertainment Tonight
(http://www.etonline.com) and more than 650 of Clear Channel Radio's local music,
news and sports stations throughout the U.S.
About Thumbplay
Thumbplay, Inc. is defining the mobile entertainment experience for
U.S. consumers. As the largest and fastest growing mobile entertainment
content destination, Thumbplay gives consumers access to the broadest and
deepest catalog in the industry, spanning audio, video and gaming content
from the leading music labels and artists, game publishers and media
companies. Its innovative delivery and marketing platform makes it easy for
users to discover, manage, store and share mobile content online and on
their wireless devices.
Headquartered in New York City, Thumbplay was founded in September 2004
by Are Traasdahl and Evan Schwartz. It is backed by Bain Capital Ventures,
SoftBank Capital, i-Hatch Ventures, Redwood Partners, New Enterprise
Associates, Meritech, Brookside Capital Partners and Cross Creek Capital.
More information can be found at http://www.thumbplay.com.
*Source: Nielsen Mobile's "Mobile Content Storefront Revenue" Report,
Q3
and Q4 2007 and Q1 2008(based on non-carrier revenue generation
at the top 4 U.S. carriers)
See Also
Search Through More Than 80,000 Pieces of Licensed Mobile Entertainment
Content
NEW YORK, June 16 -- Thumbplay(R) (http://www.thumbplay.com), the
#1 mobile entertainment destination in the U.S.*, has launched the beta
version of an innovative mobile search service that allows cell phone users
in the United States to instantly search for and purchase ringtones, games,
videos and wallpapers from their mobile phone or handheld device (like a
Blackberry).
Thumbplay's GET is an SMS-based search option that allows consumers to
search for mobile entertainment content from wherever they are. All a
consumer needs to do is send a text message with the word "Get" plus any
artist or song name to THUMB (84862) to find and download content from
their favorite artists. For example, to find all mobile content associated
with the band Coldplay, a user would simply send an SMS message to THUMB
(84862) with the phrase "Get Coldplay" and a link to relevant content
(e.g., songs, videos, wallpapers and/or associated games) will be sent back
from Thumbplay to their mobile phone within seconds. A user would then
follow this link (as long as their phone has Web access to retrieve the
links) to a large menu of licensed Coldplay content found in Thumbplay's
catalog, which they can browse without commitment and then purchase and
download.
"Thumbplay has maintained and grown its leadership position in the
industry by providing our consumers with the largest catalog and allowing
them to quickly and easily search for, find and download the mobile content
they want," said Are Traasdahl, CEO and founder of Thumbplay. "With GET,
we've made it simple for consumers to find and purchase their favorite
mobile content whenever and wherever they are -- even if they're not near a
computer."
GET streamlines the way consumers can search for, browse and download
mobile entertainment content from their cell phones, regardless of their
location. It enables them to find relevant content by keyword -- such as an
artist's name or a song or game title -- within Thumbplay's extensive
mobile catalog, which currently includes more than 80,000 pieces of
licensed audio, video and gaming content from many of the world's leading
music labels, artists and game publishers, as well as media and
entertainment companies.
Thumbplay has built a strong consumer following and gained broad
recognition as a leader in the direct-to-consumer mobile content space.
During the last quarter of 2007, Thumbplay announced deals to integrate its
mobile entertainment content catalog into the Web and mobile portals of AOL
and MSN Mobile, as well as iLike, one of the Web's leading social music
discovery services.
Earlier this year, Thumbplay signed a digital distribution agreement to
add content from Sony BMG Music Entertainment's artists to Thumbplay's
already diverse mobile entertainment catalog, as well as to roll out mobile
content stores on the Web sites for Entertainment Tonight
(http://www.etonline.com) and more than 650 of Clear Channel Radio's local music,
news and sports stations throughout the U.S.
About Thumbplay
Thumbplay, Inc. is defining the mobile entertainment experience for
U.S. consumers. As the largest and fastest growing mobile entertainment
content destination, Thumbplay gives consumers access to the broadest and
deepest catalog in the industry, spanning audio, video and gaming content
from the leading music labels and artists, game publishers and media
companies. Its innovative delivery and marketing platform makes it easy for
users to discover, manage, store and share mobile content online and on
their wireless devices.
Headquartered in New York City, Thumbplay was founded in September 2004
by Are Traasdahl and Evan Schwartz. It is backed by Bain Capital Ventures,
SoftBank Capital, i-Hatch Ventures, Redwood Partners, New Enterprise
Associates, Meritech, Brookside Capital Partners and Cross Creek Capital.
More information can be found at http://www.thumbplay.com.
*Source: Nielsen Mobile's "Mobile Content Storefront Revenue" Report,
Q3
and Q4 2007 and Q1 2008(based on non-carrier revenue generation
at the top 4 U.S. carriers)
See Also
Friday, 6 June 2008
Jennifer Lopez - Lopez Takes Over Nannying Duties
JENNIFER LOPEZ is refusing to find a new nanny to look after her baby twins, because she wants to be a full-time mum.
The nanny Lopez and husband Marc Anthony hired to look after three-month-old twins Max and Emme left the job last month (Apr08), and, instead of replacing her, Lopez is caring for the pair around the clock.
A friend tells Us Weekly, "She's beyond hands-on."
And both Lopez and Anthony plan to put family first and their careers second for at least the next 12 months: "They both told their managers that the next year would be all about family."
Meanwhile, Anthony will take his wife and twins with him when he tours Spain next month (Jun08).
See Also
Saturday, 31 May 2008
DigitalRodeo.com Lines Up Entertainment for Rhinestone Cure
NASHVILLE, Tenn., May 29 -- DigitalRodeo.com has announced
today that they have coordinated all the entertainment for Rhinestone Cure,
a non-profit, charitable event on Saturday, May 31st at Hotel Indigo, on
West End, from 7pm until midnight.
DigitalRodeo.com is an exclusive country music community that offers a
place for you to connect with artists, friends and fans as well as have an
unlimited opportunity to discover the world of country music quick, easy
and free!
One of the hottest entertainers coming for the evening are Married by
Elvis. Over the past 6 years, MBE worked hard to gain notoriety as San
Diego's favorite country band. They recently completed a 2 1/2 month stint
as the official house band for KSON's Hometown Handshake Tour (San Diego's
1 Country Radio Station), and have been featured on NBC, FOX, KUSI and in
the San Diego Union-Tribune, 944 & Riviera Magazine, San Diego Magazine and
Living In Style magazine ... just to name a few!
"The entertainment lined up for the evening includes Jazz sung by Suzie
Evjen of New York, country music greats such as James Intveld, and local
celebrity DJs. This is an event you will not want to miss and you will want
to bid on the Auction item, the Victory Motorcycle signed by Merle Haggard
at DigitalRodeo.com," said Stephen Shutts of DigitalRodeo.com.
"I have been blessed with an amazing life," says Morelia. "This
organization is my way of giving back. Diabetes is a serious disease that
can be managed with proper lifestyle but we still need a cure." After this
event, a telethon to fight diabetes would be the opportunity to utilize
Morelia's friends and many luminaries she has known since her childhood.
If you are interested in being a part of the Rhinestone Cure and
celebrating Morelia's 40th birthday party for a $40.00 Donation, please
call 615-829-2451 or visit Manuel American Designs, Inc. at 1922 Broadway
where Morelia is VP of public relations or go to http://www.rhinestonecure.org
About Rhinestone Cure:
Rhinestone Cure is a non-profit, charitable organization that raises
the awareness of Diabetes and the celebration of life! This organization's
primary focus is to create a telethon on network television for Diabetes
Awareness as well as create on-going "glitzy & entertaining" fundraising
events & activities that stage social & educational efforts illuminating
the realism of living with Diabetes and helping those affected by this
disease make positive choices. Rhinestone Cure cultivates participation
domestically & internationally to work in conjunction with businesses,
medical community, fashion industry, entertainment media & communication
firms, as well as private individuals united in the common goal to improve
the quality of life by defeating and finding a cure for Diabetes. Call
615-829-2451 http://www.rhinestonecure.org
See Also
today that they have coordinated all the entertainment for Rhinestone Cure,
a non-profit, charitable event on Saturday, May 31st at Hotel Indigo, on
West End, from 7pm until midnight.
DigitalRodeo.com is an exclusive country music community that offers a
place for you to connect with artists, friends and fans as well as have an
unlimited opportunity to discover the world of country music quick, easy
and free!
One of the hottest entertainers coming for the evening are Married by
Elvis. Over the past 6 years, MBE worked hard to gain notoriety as San
Diego's favorite country band. They recently completed a 2 1/2 month stint
as the official house band for KSON's Hometown Handshake Tour (San Diego's
1 Country Radio Station), and have been featured on NBC, FOX, KUSI and in
the San Diego Union-Tribune, 944 & Riviera Magazine, San Diego Magazine and
Living In Style magazine ... just to name a few!
"The entertainment lined up for the evening includes Jazz sung by Suzie
Evjen of New York, country music greats such as James Intveld, and local
celebrity DJs. This is an event you will not want to miss and you will want
to bid on the Auction item, the Victory Motorcycle signed by Merle Haggard
at DigitalRodeo.com," said Stephen Shutts of DigitalRodeo.com.
"I have been blessed with an amazing life," says Morelia. "This
organization is my way of giving back. Diabetes is a serious disease that
can be managed with proper lifestyle but we still need a cure." After this
event, a telethon to fight diabetes would be the opportunity to utilize
Morelia's friends and many luminaries she has known since her childhood.
If you are interested in being a part of the Rhinestone Cure and
celebrating Morelia's 40th birthday party for a $40.00 Donation, please
call 615-829-2451 or visit Manuel American Designs, Inc. at 1922 Broadway
where Morelia is VP of public relations or go to http://www.rhinestonecure.org
About Rhinestone Cure:
Rhinestone Cure is a non-profit, charitable organization that raises
the awareness of Diabetes and the celebration of life! This organization's
primary focus is to create a telethon on network television for Diabetes
Awareness as well as create on-going "glitzy & entertaining" fundraising
events & activities that stage social & educational efforts illuminating
the realism of living with Diabetes and helping those affected by this
disease make positive choices. Rhinestone Cure cultivates participation
domestically & internationally to work in conjunction with businesses,
medical community, fashion industry, entertainment media & communication
firms, as well as private individuals united in the common goal to improve
the quality of life by defeating and finding a cure for Diabetes. Call
615-829-2451 http://www.rhinestonecure.org
See Also
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